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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC7
All Species:
17.88
Human Site:
S450
Identified Species:
49.17
UniProt:
O00311
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00311
NP_001127891.1
574
63888
S450
F
G
K
S
I
L
C
S
K
E
V
P
A
Q
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001097186
574
63766
S450
F
G
K
S
I
L
C
S
K
E
V
P
A
Q
D
Dog
Lupus familis
XP_537080
756
83548
S632
F
G
K
S
I
L
C
S
K
E
V
P
A
Q
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z0H0
564
62734
S441
F
G
K
S
V
L
C
S
K
E
V
P
A
Q
D
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521163
410
45484
G292
K
K
V
V
S
T
K
G
L
N
S
G
V
M
R
Chicken
Gallus gallus
XP_422347
564
62394
T446
F
G
K
S
V
L
C
T
Q
V
V
P
A
Q
N
Frog
Xenopus laevis
NP_001081878
483
53563
E365
K
S
V
L
C
S
K
E
L
P
S
K
D
L
R
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785538
591
65818
A471
T
E
E
T
T
E
A
A
K
V
N
G
K
N
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P06243
507
58302
E388
C
T
I
G
T
F
P
E
Y
S
V
A
F
E
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
96.8
68.9
N.A.
78
N.A.
N.A.
61.3
67.2
55.4
N.A.
N.A.
N.A.
N.A.
N.A.
36.7
Protein Similarity:
100
N.A.
97.7
71.5
N.A.
84.8
N.A.
N.A.
65.6
78.7
66.9
N.A.
N.A.
N.A.
N.A.
N.A.
54.4
P-Site Identity:
100
N.A.
100
100
N.A.
93.3
N.A.
N.A.
0
66.6
0
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
0
93.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
12
12
0
0
0
12
56
0
0
% A
% Cys:
12
0
0
0
12
0
56
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
45
% D
% Glu:
0
12
12
0
0
12
0
23
0
45
0
0
0
12
0
% E
% Phe:
56
0
0
0
0
12
0
0
0
0
0
0
12
0
0
% F
% Gly:
0
56
0
12
0
0
0
12
0
0
0
23
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
12
0
34
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
23
12
56
0
0
0
23
0
56
0
0
12
12
0
0
% K
% Leu:
0
0
0
12
0
56
0
0
23
0
0
0
0
12
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
12
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
12
12
0
0
12
12
% N
% Pro:
0
0
0
0
0
0
12
0
0
12
0
56
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
12
0
0
0
0
56
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
23
% R
% Ser:
0
12
0
56
12
12
0
45
0
12
23
0
0
0
0
% S
% Thr:
12
12
0
12
23
12
0
12
0
0
0
0
0
0
12
% T
% Val:
0
0
23
12
23
0
0
0
0
23
67
0
12
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _